Gather The Information About Diabetes Gene

Science has now proven that the development of diabetes mellitus correlates with the diabetes gene, meaning diabetes often runs in families, passing to blood-related family members. Both type 1 (insulin-dependent) and type 2 diabetes (non-insulin dependent) diabetes emerge because of environmental and genetic interaction.

However, two rare kinds of diabetes – maturity onset diabetes and mitochondrial DNA-related diabetes – are strictly genetic in nature. Geneticists have recently discovered over 20 different types of genes associated with the appearance of diabetes in individuals with a family history of diabetes.

Diabetes Gene

Genetics of Type 1 Diabetes

One particular type 1 diabetes gene, called the insulin gene, appears to play a predominant role in causing this disease. Another one is the human leukocyte antigen, or HLA region of a chromosome, which contains genes influencing the functioning of the immune system. Researchers have discovered two genes existing in this HLA section of chromosomes, which appears to provoke around 50 percent of the risk to develop diabetes when these genes are inherited from your parents.

You can inherit a gene called “DR” from both your father and mother, and when the two parts of this gene come together during recombination, the risk that you will be diagnosed with diabetes at some point in your life increases. However, only around 3 percent of the population has inherited both DR genes, with the others inheriting one or the other.

The insulin gene is found on a specific area of DNA, which produces codes influencing production of protein insulin. When alterations to DNA structure occur, this diabetes gene increases a person’s risk for developing diabetes. This region of DNA is comprised of different lengths of DNA strands. When someone inherits two small VNTR regions (Variable Number of Tandem Repeats), they are between two and five times more apt to be affected by type 1 diabetes than someone who has one long VNTR.

Genetics of Type 2 Diabetes

Genetics of Type 2 Diabetes

People suffering from type 2 diabetes will probably know a blood relative who also has diabetes more often than does someone diagnosed with type 1 diabetes. This may be because type 2 diabetes is more common than any other form of diabetes and to environmental factors promoting obesity and a sedentary lifestyle. Because of these variables affecting the appearance of type 2 diabetes in families, geneticists are still sure of the role that genetics play in someone developing type 2 diabetes.

An exception to this lack of evidence for a potential diabetes gene to be involved in type 2 diabetes is the situation where siblings or parent/child who are healthy, not overweight and moderately active both develop diabetes. In this case, the existence of a hereditary factor is definitely possible and the potential for diabetes to be passed on to children of the siblings and grandchildren is highly probable.

Environmental Risk Factors

Families, who exhibit generational appearances of diabetes, may be more influenced by environmental factors than the genetic component. For example, families with overeating, unhealthy food habits and lack of physical exercise normal will act as triggers to any genes carrying alleles (markers) promoting diabetic conditions. This environmental aspect of diabetes is especially associated with type 2 diabetes, which you can manage by following a well-balanced diet, engaging in daily physical activity, and maintaining weight at an optimal level for your body type and style.

DNA Testing for Diabetes

If you suspects you may be carrying some form of genetic susceptibility to diabetes you can now purchase DTC kits for testing without visiting your physician. Direct-to-consumer kits, or DTC kits, determine whether someone may develop certain cancers, heart disease and diabetes. However, receiving a low-risk result from a genetic diabetes screening does not mean that you cannot develop diabetes, especially if you deliberately neglect your general health.

Because preventative measures do not inhibit the appearance of type 1 diabetes, people receiving positive genetic results for type 1 diabetes can at least delay or reduce the severity of the disease by adopting a lifestyle counteractive to obesity, high blood pressure and heart disease.

Fortunately, the ability to accurately discover the presence of a diabetes gene in your family provides the chance to enact preemptive strategies that will directly reduce the risk of developing diabetes.



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